ATR, activated by replication stress, protects replication forks locally and suppresses origin
firing globally. Here, we show that these functions of ATR are mechanistically coupled. …

Intrinsically disordered proteins can phase separate from the soluble intracellular space,
and tend to aggregate under pathological conditions. The physiological functions and …

Poly-ADP-ribosylation is a post-translational modification catalyzed by PARP enzymes with
roles in transcription and chromatin biology. Here we show that distinct macrodomains, …

Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide
adenine dinucleotide (NAD) as a substrate. Despite intensive research on the cellular …

The genus Sorangium synthesizes approximately half of the secondary metabolites isolated
from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete …

Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are
readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved are …

Poly(ADP-ribos)ylation (PARylation) is a reversible posttranslational modification found in
higher eukaryotes. However, little is known about PARylation acceptor proteins. Here, we …

The DNA damage response ( DDR ) generates transient repair compartments to concentrate
repair proteins and activate signaling factors. The physicochemical properties of these …

Histone ubiquitylation is a prominent response to DNA double-strand breaks (DSBs), but
how these modifications are confined to DNA lesions is not understood. Here, we show that …

Eukaryotic cells are complex structures capable of coordinating numerous biochemical reactions
in space and time. Key to such coordination is the subdivision of intracellular space into …