The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …

Long-read sequencing technologies have now reached a level of accuracy and yield that
allows their application to variant detection at a scale of tens to thousands of samples. …

Uncovering the genetic basis of species diversification is a central goal in evolutionary
biology. Yet, the link between the accumulation of genomic changes during population …

Structural variation (SV) constitutes an important type of genetic mutations providing the raw
material for evolution. Here, we uncover the genome-wide spectrum of intra- and …

In addition to the canonical right-handed double helix, other DNA structures, termed ‘non-B
DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular …

The genomics revolution has led to the sequencing of a large variety of nonmodel organisms
often referred to as “whole” or “complete” genome assemblies. But how complete are these…

Remotely controlled, unmanned aerial vehicles (UAVs) promise to be of high potential for a
variety of applications in ecological and behavioural research. Off‐the‐shelf solutions have …

Accurate and contiguous genome assembly is key to a comprehensive understanding of the
processes shaping genomic diversity and evolution. Yet, it is frequently constrained by …

Approximately 13% of the human genome at certain motifs have the potential to form noncanonical
(non-B) DNA structures (eg, G-quadruplexes, cruciforms, and Z-DNA), which regulate …

G-quadruplexes (G4s), a type of non-B DNA, play important roles in a wide range of molecular
processes, including replication, transcription, and translation. Genome integrity relies on …