Cardiovascular disease is the leading cause of death worldwide. Advanced insights into
disease mechanisms and therapeutic strategies require a deeper understanding of the …

STRIDE is a software tool for secondary structure assignment from atomic resolution protein
structures. It implements a knowledge-based algorithm that makes combined use of …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end-…

Immune cells regulate a hypertonic microenvironment in the skin; however, the biological
advantage of increased skin Na + concentrations is unknown. We found that Na + accumulated …

Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic
cardiomyopathy (ACM) convey high risks for the development of heart failure through …

A high intake of dietary salt (NaCl) has been implicated in the development of hypertension,
chronic inflammation, and autoimmune diseases. We have recently shown that salt has a …

We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 …

Combined analyses of gene networks and DNA sequence variation can provide new
insights into the aetiology of common diseases that may not be apparent from genome-wide …

The transcription factor affinity prediction (TRAP) method calculates the affinity of transcription
factors for DNA sequences on the basis of a biophysical model. This method has proven to …

In recent years, functional genomics approaches combining genetic information with bulk
RNA-sequencing data have identified the downstream expression effects of disease-…