User profiles for Matthias P. Lutolf
 | Matthias P. LutolfEPFL Verified email at epfl.ch Cited by 37828 |
Designing materials to direct stem-cell fate
MP Lutolf, PM Gilbert, HM Blau - Nature, 2009 - nature.com
Proper tissue function and regeneration rely on robust spatial and temporal control of
biophysical and biochemical microenvironmental cues through mechanisms that remain poorly …
biophysical and biochemical microenvironmental cues through mechanisms that remain poorly …
Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture
Stem cells that naturally reside in adult tissues, such as muscle stem cells (MuSCs), exhibit
robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered …
robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered …
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
MP Lutolf, JA Hubbell - Nature biotechnology, 2005 - nature.com
New generations of synthetic biomaterials are being developed at a rapid pace for use as
three-dimensional extracellular microenvironments to mimic the regulatory characteristics of …
three-dimensional extracellular microenvironments to mimic the regulatory characteristics of …
Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics
MP Lutolf, JL Lauer-Fields… - Proceedings of the …, 2003 - National Acad Sciences
Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics
of native provisional extracellular matrices: a combination of integrin-binding sites and …
of native provisional extracellular matrices: a combination of integrin-binding sites and …
Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
We have engineered synthetic poly(ethylene glycol) (PEG)–based hydrogels as cell-ingrowth
matrices for in situ bone regeneration. These networks contain a combination of pendant …
matrices for in situ bone regeneration. These networks contain a combination of pendant …
[HTML][HTML] Engineering organoids
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …
enormous interest for modelling tissue development and disease, and for personalized …
Designer matrices for intestinal stem cell and organoid culture
Epithelial organoids recapitulate multiple aspects of real organs, making them promising
models of organ development, function and disease 1 , 2 , 3 . However, the full potential of …
models of organ development, function and disease 1 , 2 , 3 . However, the full potential of …
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of the …
susceptible to senescence during aging. We demonstrate the importance of the amount of the …
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis
Epithelial organoids, such as those derived from stem cells of the intestine, have great potential
for modelling tissue and disease biology 1 , 2 , 3 – 4 . However, the approaches that are …
for modelling tissue and disease biology 1 , 2 , 3 – 4 . However, the approaches that are …
Progress and potential in organoid research
G Rossi, A Manfrin, MP Lutolf - Nature Reviews Genetics, 2018 - nature.com
Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However, …
hindered, particularly in humans, by sample accessibility and ethical concerns. However, …