Mechanistic target of rapamycin (mTOR) regulates cell growth, metabolism and aging in
response to nutrients, cellular energy stage and growth factors. mTOR is frequently up-regulated …

Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage,
HBV-associated HCCs. Here we present an integrated proteogenomic analysis of HCCs …

Emerging evidence points toward an intricate relationship between the pandemic of coronavirus
disease 2019 (COVID-19) and diabetes. While preexisting diabetes is associated with …

Hepatocellular carcinoma (HCC) is among the leading causes of cancer‐related death.
Despite the advances in diagnosis and management of HCC, the biology of this tumor remains …

Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the second
most frequent cause of cancer-related mortality worldwide. The multikinase inhibitor sorafenib …

The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the …

Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily lead
to upper respiratory tract infection and its sequelae frequently dominate the clinical course …

Amplification of the epidermal growth factor receptor (EGFR) gene is one of the most common
oncogenic alterations in glioblastoma (45%) making it a prime target for therapy. However, …

Background A dysregulated immune response is considered one of the major factors leading
to severe COVID-19. Previously described mechanisms include the development of a …