User profiles for Matthias Steinrücken

Matthias Steinruecken

University of Chicago, Department of Ecology & Evolution
Verified email at uchicago.edu
Cited by 2086

Genomic evidence for the Pleistocene and recent population history of Native Americans

M Raghavan, M Steinrücken, K Harris, S Schiffels… - Science, 2015 - science.org
INTRODUCTION The consensus view on the peopling of the Americas is that ancestors of
modern Native Americans entered the Americas from Siberia via the Bering Land Bridge and …

[HTML][HTML] Evolution of immune genes is associated with the Black Death

…, D Missiakas, GA Rouleau, M Steinrücken… - Nature, 2022 - nature.com
Infectious diseases are among the strongest selective pressures driving human evolution 1 ,
2 . This includes the single greatest mortality event in recorded history, the first outbreak of …

Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans

JV Moreno-Mayar, BA Potter, L Vinner, M Steinrücken… - Nature, 2018 - nature.com
Despite broad agreement that the Americas were initially populated via Beringia, the land
bridge that connected far northeast Asia with northwestern North America during the …

[PDF][PDF] Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders

…, E Benito, Q Zhu, C Lee, F Antonacci, M Steinrücken… - Cell, 2022 - cell.com
Unlike copy number variants (CNVs), inversions remain an underexplored genetic variation
class. By integrating multiple genomic technologies, we discover 729 inversions in 41 …

[HTML][HTML] Parental relatedness through time revealed by runs of homozygosity in ancient DNA

H Ringbauer, J Novembre, M Steinrücken - Nature communications, 2021 - nature.com
Parental relatedness of present-day humans varies substantially across the globe, but little
is known about the past. Here we analyze ancient DNA, leveraging that parental relatedness …

Inference of complex population histories using whole-genome sequences from multiple populations

M Steinrücken, J Kamm, JP Spence… - Proceedings of the …, 2019 - National Acad Sciences
There has been much interest in analyzing genome-scale DNA sequence data to infer
population histories, but inference methods developed hitherto are limited in model complexity …

Model‐based detection and analysis of introgressed Neanderthal ancestry in modern humans

M Steinrücken, JP Spence, JA Kamm… - Molecular …, 2018 - Wiley Online Library
Genetic evidence has revealed that the ancestors of modern human populations outside Africa
and their hominin sister groups, notably Neanderthals, exchanged genetic material in the …

A simple method for finding explicit analytic transition densities of diffusion processes with general diploid selection

YS Song, M Steinrücken - Genetics, 2012 - academic.oup.com
The transition density function of the Wright–Fisher diffusion describes the evolution of
population-wide allele frequencies over time. This function has important practical applications in …

A modified lookdown construction for the Xi-Fleming-Viot process with mutation and populations with recurrent bottlenecks

M Birkner, J Blath, M Möhle, M Steinrücken… - arXiv preprint arXiv …, 2008 - arxiv.org
Let $\Lambda$ be a finite measure on the unit interval. A $\Lambda$-Fleming-Viot process
is a probability measure valued Markov process which is dual to a coalescent with multiple …

Inference of population history using coalescent HMMs: review and outlook

JP Spence, M Steinrücken, J Terhorst… - Current opinion in genetics …, 2018 - Elsevier
Studying how diverse human populations are related is of historical and anthropological
interest, in addition to providing a realistic null model for testing for signatures of natural …