The recently discovered CRISPR (clustered regularly interspaced short palindromic repeat)
defense system protects bacteria and archaea against mobile genetic elements. This …

All organisms need to continuously adapt to changes in their environment. Through horizontal
gene transfer, bacteria and archaea can rapidly acquire new traits that may contribute to …

Prokaryotes acquire virus resistance by integrating short fragments of viral nucleic acid into
clusters of regularly interspaced short palindromic repeats (CRISPRs). Here we show how …

Prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR)/Cas (CRISPR-associated
sequences) systems provide adaptive immunity against viruses when a spacer …

The CRISPR (clustered regularly interspaced short palindromic repeats) immune system in
prokaryotes uses small guide RNAs to neutralize invading viruses and plasmids. In …

The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain incorporated
sequence tags from viruses and plasmids. Using small guide RNA molecules, these …

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for
malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to …

Bacteria and archaea acquire resistance to viruses and plasmids by integrating short
fragments of foreign DNA into clustered regularly interspaced short palindromic repeats (CRISPRs)…

RNA interference is widely distributed in eukaryotes and has a variety of functions, including
antiviral defence and gene regulation 1 , 2 . All RNA interference pathways use small single-…

The recently discovered prokaryotic CRISPR/Cas defence system provides immunity against
viral infections and plasmid conjugation. It has been demonstrated that in Escherichia coli …