DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular
processes including genome regulation, development and disease. Here we present the …

Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine
and studies of disease and development. Somatic cell reprogramming involves epigenomic …

Regulation of gene expression by DNA methylation is crucial for defining cellular identities
and coordinating organism-wide developmental programs in many organisms. In plants, …

Human embryonic stem cells (hESCs) share an identical genome with lineage-committed
cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse …

Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling
methods. The four most frequently used sequencing-based technologies are the bisulfite…

Natural epigenetic variation provides a source for the generation of phenotypic diversity, but
to understand its contribution to such diversity, its interaction with genetic variation requires …

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic alterations
during tumorigenesis including aberrant DNA hypermethylation of tumor suppressors, …

The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of
genomic loci 1 . Recent work suggested that rather than up- and downregulating selected …

10.7554/eLife.00675.001 The gaseous plant hormone ethylene regulates a multitude of
growth and developmental processes. How the numerous growth control pathways are …

Background Transcriptional profiling using microarrays provides a unique opportunity to
decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able …