To study brain function, preclinical research heavily relies on animal monitoring and the
subsequent analyses of behavior. Commercial platforms have enabled semi high-throughput …

The locus coeruleus (LC) is a region in the brainstem that produces noradrenaline and is
involved in both normal and pathological brain function. Pupillometry, the measurement of …

The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC …

The acute stress response mobilizes energy to meet situational demands and re-establish
homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief …

Background Acutely stressful experiences can trigger neuropsychiatric disorders and impair
cognitive processes by altering hippocampal function. Although the intrinsic organization of …

Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic
goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist …

Noradrenaline (NA) release from the brainstem nucleus locus coeruleus (LC) changes
activity and connectivity in neuronal networks across the brain, thus modulating multiple …

Exposure to an acute stressor triggers a complex cascade of neurochemical events in the
brain. However, deciphering their individual impact on stress-induced molecular changes …

Exploration is essential for survival because it allows animals to gather information about their
environment. Rearing is a classic exploratory behavior, during which an animal transiently …

Chronic stress exposure in adolescence can lead to a lasting change in stress responsiveness
later in life and is associated with increased mental health issues in adulthood. Here we …