The innate immune system, the primary defense mechanism of higher organisms against
pathogens including viruses, senses pathogen-associated molecular patterns (PAMPs). In …

Aberrant detection of endogenous nucleic acids by the immune system can cause
inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous …

Replication of viruses requires interaction with host cell factors and repression of innate
immunity. Recent findings suggest that a subset of intracellular mono-ADP-ribosylating PARPs, …

A subset of intracellular mono-ADP-ribosyltransferases diphtheria toxin-like (ARTDs, aka
mono-PARPs) is induced by type I interferons. Some of these mono-ARTDs feature antiviral …

Chikungunya (CHIKV) and Sindbis (SINV) are arboviruses belonging to the alphavirus genus
within the Togaviridae family. They cause frequent epidemics of febrile illness and long-…

Background The zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the
replication of various viruses by degradation of certain viral mRNA. However, previous study …

Herpes simplex virus (HSV) is a neurotropic virus that establishes lifelong latent infection in
human ganglion sensory neurons. This unique life cycle necessitates an intimate relation …

Background Dendritic cells (DCs) are among the first cells to encounter HIV-1 and play
important roles in viral transmission and pathogenesis. Immature DCs allow productive HIV-1 …

Cellular cross-talk between ubiquitination and other posttranslational modifications
contributes to the regulation of numerous processes. One example is ADP-ribosylation of the …

… hildegarde verherstraeten, oSu. All rights reserved. except for brief quotations in critical …
hildegarde verherstraeten, oSu, and soon afterwards i received the information i requested, …