TP53 gene mutations are one of the most frequent somatic events in cancer. The IARC TP53
Database ( http://p53.iarc.fr ) is a popular resource that compiles occurrence and phenotype …

Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other
lung cancers, but their precise relationship has remained unclear. Here we perform a …

Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing data, …

Cutaneous beta human papillomavirus (HPV) types are suspected to be involved, together
with ultraviolet (UV) radiation, in the development of non-melanoma skin cancer (NMSC). …

Aflatoxin B1 (AFB1) is a mutagen and IARC (International Agency for Research on Cancer)
Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here, we present the first …

Experimental models that recapitulate mutational landscapes of human cancers are needed
to decipher the rapidly expanding data on human somatic mutations. We demonstrate that …

Objectives The accumulation of tumor‐associated macrophages (TAMs) is correlated with
poor clinical outcome, but the mechanisms governing their differentiation from circulating …

Humans are frequently exposed to acrylamide, a probable human carcinogen found in
commonplace sources such as most heated starchy foods or tobacco smoke. Prior evidence has …

Background The nature of somatic mutations observed in human tumors at single gene or
genome-wide levels can reveal information on past carcinogenic exposures and mutational …

Aristolochic acid (AA) is a potent dietary cytotoxin and carcinogen, and an established
etiological agent underlying severe human nephropathies and associated upper urinary tract …