Protein misfolding in the endoplasmic reticulum (ER) leads to cell death through PERK-mediated
phosphorylation of eIF2α, although the mechanism is not understood. ChIP-seq and …

Background— Recent studies have identified critical roles for microRNAs (miRNAs) in a
variety of cellular processes, including regulation of cardiomyocyte death. However, the …

Motivation: Metabolomics is a rapidly evolving field that holds promise to provide insights into
genotype–phenotype relationships in cancers, diabetes and other complex diseases. One …

The task of predicting the interactions between drugs and targets plays a key role in the process
of drug discovery. There is a need to develop novel and efficient prediction approaches …

Background The small sample sizes often used for microarray experiments result in poor
estimates of variance if each gene is considered independently. Yet accurately estimating …

Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset
Alzheimer’s disease (LOAD), but little has been done on a genome-wide scale to identify potential …

Motivation: DNA methylation plays critical roles in gene regulation and cellular specification
without altering DNA sequences. The wide application of reduced representation bisulfite …

Motivation Analysis of next-generation sequencing data often results in a list of genomic
regions. These may include differentially methylated CpGs/regions, transcription factor binding …

Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1 (IDH1
R132H ) are younger at diagnosis and live longer. IDH1 mutations co-occur with other …

Motivation: The elucidation of biological pathways enriched with differentially expressed genes
has become an integral part of the analysis and interpretation of microarray data. Several …