In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance: …

The t(6;11)(q27;q23) is a recurrent chromosomal rearrangement that encodes the MLLAF6
fusion oncoprotein and is observed in patients with diverse hematologic malignancies. The …

The availability of nucleotides has a direct impact on transcription. The inhibition of
dihydroorotate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing …

The aim of this study was to determine the prognostic value of quantitative fluorodeoxyglucose
( FDG ) measurements (maximum standardized uptake value [ SUV max ], metabolic …

Homeotic (HOX) genes are dysregulated in multiple malignancies, including several AML
subtypes. We demonstrate that H3K79 dimethylation (H3K79me2) is converted to …

Deciphering the genomic regulatory code of enhancers is a key challenge in biology because
this code underlies cellular identity. A better understanding of how enhancers work will …

Melanoma is the most aggressive and deadliest form of skin cancer. A detailed knowledge
of the cellular, molecular, and genetic events underlying melanoma progression is highly …

BACKGROUND: In this retrospective, single‐institution study, the authors examine the
maximum standardized uptake value (SUVmax) on positron emission tomography/computed …

Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent
genetic drivers of metastasis, while identifying common transcriptional states correlating with …

“Which drug should I prescribe to the cancer patient in front of me?” This question is an
inevitable riddle for many oncologists. While the list of US Food and Drug Administration-…