User profiles for Max F. K. Happel
Max FK HappelMSB Medical School Berlin | Leibniz-Institute for Neurobiology Magdeburg Verified email at lin-magdeburg.de Cited by 996 |
Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input
MFK Happel, M Jeschke, FW Ohl - Journal of Neuroscience, 2010 - Soc Neuroscience
Primary sensory cortex integrates sensory information from afferent feedforward thalamocortical
projection systems and convergent intracortical microcircuits. Both input systems have …
projection systems and convergent intracortical microcircuits. Both input systems have …
Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex
MFK Happel, H Niekisch… - Proceedings of the …, 2014 - National Acad Sciences
During brain maturation, the occurrence of the extracellular matrix (ECM) terminates juvenile
plasticity by mediating structural stability. Interestingly, enzymatic removal of the ECM …
plasticity by mediating structural stability. Interestingly, enzymatic removal of the ECM …
Dopamine-modulated recurrent corticoefferent feedback in primary sensory cortex promotes detection of behaviorally relevant stimuli
MFK Happel, M Deliano, J Handschuh… - Journal of …, 2014 - Soc Neuroscience
Dopaminergic neurotransmission in primary auditory cortex (AI) has been shown to be
involved in learning and memory functions. Moreover, dopaminergic projections and D 1 /D 5 …
involved in learning and memory functions. Moreover, dopaminergic projections and D 1 /D 5 …
[HTML][HTML] A role for auditory corticothalamic feedback in the perception of complex sounds
Feedback signals from the primary auditory cortex (A1) can shape the receptive field properties
of neurons in the ventral division of the medial geniculate body (MGBv). However, the …
of neurons in the ventral division of the medial geniculate body (MGBv). However, the …
[HTML][HTML] Dopamine receptor activation modulates the integrity of the perisynaptic extracellular matrix at excitatory synapses
…, H Niekisch, A Blondiaux, CE Gee, MFK Happel… - Cells, 2020 - mdpi.com
In the brain, Hebbian-type and homeostatic forms of plasticity are affected by neuromodulators
like dopamine (DA). Modifications of the perisynaptic extracellular matrix (ECM), which …
like dopamine (DA). Modifications of the perisynaptic extracellular matrix (ECM), which …
[HTML][HTML] Noise trauma induced neural plasticity throughout the auditory system of Mongolian gerbils: differences between tinnitus developing and non-developing …
In this study, we describe differences between neural plasticity in auditory cortex (AC) of
animals that developed subjective tinnitus (group T) after noise-induced hearing loss (NIHL) …
animals that developed subjective tinnitus (group T) after noise-induced hearing loss (NIHL) …
Dopaminergic impact on local and global cortical circuit processing during learning
MFK Happel - Behavioural brain research, 2016 - Elsevier
We have learned to detect, predict and behaviorally respond to important changes in our
environment on short and longer time scales. Therefore, brains of humans and higher animals …
environment on short and longer time scales. Therefore, brains of humans and higher animals …
Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex
…, S Aksit, M Deliano, FW Ohl, MFK Happel - The Journal of …, 2020 - Wiley Online Library
Key points Ketamine is a common anaesthetic agent used in research and more recently as
medication in treatment of depression. It has known effects on inhibition of interneurons and …
medication in treatment of depression. It has known effects on inhibition of interneurons and …
[HTML][HTML] Neuroplastin expression is essential for hearing and hair cell PMCA expression
…, ED Gundelfinger, M Vollmer, MFK Happel… - Brain Structure and …, 2021 - Springer
Hearing deficits impact on the communication with the external world and severely compromise
perception of the surrounding. Deafness can be caused by particular mutations in the …
perception of the surrounding. Deafness can be caused by particular mutations in the …
[HTML][HTML] Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
…, S Vieweg, FW Ohl, MT Lippert, MFK Happel - Scientific Reports, 2019 - nature.com
Reward associations during auditory learning induce cortical plasticity in the primary auditory
cortex. A prominent source of such influence is the ventral tegmental area (VTA), which …
cortex. A prominent source of such influence is the ventral tegmental area (VTA), which …