User profiles for Max F. K. Happel

Max FK Happel

MSB Medical School Berlin | Leibniz-Institute for Neurobiology Magdeburg
Verified email at lin-magdeburg.de
Cited by 996

Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input

MFK Happel, M Jeschke, FW Ohl - Journal of Neuroscience, 2010 - Soc Neuroscience
Primary sensory cortex integrates sensory information from afferent feedforward thalamocortical
projection systems and convergent intracortical microcircuits. Both input systems have …

Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex

MFK Happel, H Niekisch… - Proceedings of the …, 2014 - National Acad Sciences
During brain maturation, the occurrence of the extracellular matrix (ECM) terminates juvenile
plasticity by mediating structural stability. Interestingly, enzymatic removal of the ECM …

Dopamine-modulated recurrent corticoefferent feedback in primary sensory cortex promotes detection of behaviorally relevant stimuli

MFK Happel, M Deliano, J Handschuh… - Journal of …, 2014 - Soc Neuroscience
Dopaminergic neurotransmission in primary auditory cortex (AI) has been shown to be
involved in learning and memory functions. Moreover, dopaminergic projections and D 1 /D 5 …

[HTML][HTML] A role for auditory corticothalamic feedback in the perception of complex sounds

NY Homma, MFK Happel, FR Nodal… - Journal of …, 2017 - Soc Neuroscience
Feedback signals from the primary auditory cortex (A1) can shape the receptive field properties
of neurons in the ventral division of the medial geniculate body (MGBv). However, the …

[HTML][HTML] Dopamine receptor activation modulates the integrity of the perisynaptic extracellular matrix at excitatory synapses

…, H Niekisch, A Blondiaux, CE Gee, MFK Happel… - Cells, 2020 - mdpi.com
In the brain, Hebbian-type and homeostatic forms of plasticity are affected by neuromodulators
like dopamine (DA). Modifications of the perisynaptic extracellular matrix (ECM), which …

[HTML][HTML] Noise trauma induced neural plasticity throughout the auditory system of Mongolian gerbils: differences between tinnitus developing and non-developing …

K Tziridis, S Ahlf, M Jeschke, MFK Happel… - Frontiers in …, 2015 - frontiersin.org
In this study, we describe differences between neural plasticity in auditory cortex (AC) of
animals that developed subjective tinnitus (group T) after noise-induced hearing loss (NIHL) …

Dopaminergic impact on local and global cortical circuit processing during learning

MFK Happel - Behavioural brain research, 2016 - Elsevier
We have learned to detect, predict and behaviorally respond to important changes in our
environment on short and longer time scales. Therefore, brains of humans and higher animals …

Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex

…, S Aksit, M Deliano, FW Ohl, MFK Happel - The Journal of …, 2020 - Wiley Online Library
Key points Ketamine is a common anaesthetic agent used in research and more recently as
medication in treatment of depression. It has known effects on inhibition of interneurons and …

[HTML][HTML] Neuroplastin expression is essential for hearing and hair cell PMCA expression

…, ED Gundelfinger, M Vollmer, MFK Happel… - Brain Structure and …, 2021 - Springer
Hearing deficits impact on the communication with the external world and severely compromise
perception of the surrounding. Deafness can be caused by particular mutations in the …

[HTML][HTML] Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex

…, S Vieweg, FW Ohl, MT Lippert, MFK Happel - Scientific Reports, 2019 - nature.com
Reward associations during auditory learning induce cortical plasticity in the primary auditory
cortex. A prominent source of such influence is the ventral tegmental area (VTA), which …