Influenza virus polymerase uses a capped primer, derived by ‘cap-snatching’ from host pre-messenger
RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to …

In plants, the AUXIN RESPONSE FACTOR (ARF) transcription factor family regulates gene
expression in response to auxin. In the absence of auxin, ARF transcription factors are …

Dengue fever is an important emerging public health concern, with several million viral infections
occurring annually, for which no effective therapy currently exists. The NS3 protein from …

Tank-binding kinase I (TBK1) plays a key role in the innate immune system by integrating
signals from pattern-recognition receptors. Here, we report the X-ray crystal structures of …

The processes of genome replication and transcription of SARS-CoV-2 represent important
targets for viral inhibition. Betacoronaviral nucleoprotein (N) is a highly dynamic cofactor of …

The plant hormone auxin is a key morphogenetic regulator acting from embryogenesis onwards.
Transcriptional events in response to auxin are mediated by the auxin response factor (…

The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated K+ channels
encodes molecular determinants for subfamily-specific assembly of α-subunits into functional …

Liquid–liquid phase separation (LLPS) is an important mechanism enabling the dynamic
compartmentalization of macromolecules, including complex polymers such as proteins and …

Acyl acid amido synthetases of the GH3 family act as critical prereceptor modulators of plant
hormone action; however, the molecular basis for their hormone selectivity is unclear. Here, …

Motivation: Individual research groups now analyze thousands of samples per year at
synchrotron macromolecular crystallography (MX) resources. The efficient management of …