The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally
deplete proteins in a range of organisms and cell types. Here, we describe a toolkit to augment …

Nematode molting is a remarkable process where animals must repeatedly build a new apical
extracellular matrix (aECM) beneath a previously built aECM that is subsequently shed. …

Single-cell transcriptomic platforms provide an opportunity to map an organism's response
to environmental cues with high resolution. Here, we applied single-nucleus RNA …

Lysosomes are an important organelle required for the degradation of a range of cellular
components. Lysosome function is critical for development and homeostasis as dysfunction can …

The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally
deplete proteins in a range of organisms and cell-types. Here, we describe a toolkit to augment …

Reproduction is a remarkably intricate process involving the interaction of multiple cell types
and organ systems unfolding over long periods of time and that culminates with the …

Nematode molting is a remarkable process where the animals must essentially build a new
epidermis underneath the old skin and then rapidly shed the old skin. The study of molting …

The auxin-inducible degron (AID) system is a widely used system to conditionally deplete
proteins. Using CRISPR/Cas9-based genome editing in C. elegans, we recently generated a …

Caenorhabditis elegans is a valuable model to study organ, tissue, and cell-type responses
to external cues. However, the nematode comprises multiple syncytial tissues with spatial …

Apical extracellular matrices (aECMs) are associated with all epithelia and form a protective
layer against biotic and abiotic threats in the environment. C. elegans molting offers a …