Macrophage-mediated programmed cell removal (PrCR) is a process essential for the
clearance of unwanted (damaged, dysfunctional, aged, or harmful) cells. The detection and …

Ovarian cancer and triple-negative breast cancer are among the most lethal diseases
affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are …

Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need
for basic studies of immunoregulation in both adaptive cell lineages and innate cell lineages…

Multiplex imaging technologies are now routinely capable of measuring more than 40
antibody-labeled parameters in single cells. However, lateral spillage of signals in densely packed …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …

Prolonged exposure of CD8 + T cells to antigenic stimulation, as in chronic viral infections,
leads to a state of diminished function termed exhaustion. We now demonstrate that even …

It is well understood that the adaptive immune response to infectious agents includes a
modulating suppressive component as well as an activating component. We now show that the …

Intratumoral heterogeneity is a seminal feature of human tumors contributing to tumor
progression and response to treatment. Current technologies are still largely unsuitable to …

Background Red blood cells circulate for ~120 days in humans and ~50 days in mice before
they are phagocytosed by macrophages in the splenic red pulp at the end of their lifespans. …

Snake-bark maple is a small, deciduous tree that grows up to 10-15 m tall, with arching
branching and a decorative bark and leaves. It is native in the mountain forests of Japan. Kyushu …