The function of a eukaryotic cell crucially depends on accurate gene transcription to ensure
the right genes are expressed whereas unrequired genes are repressed. Therefore, arguably…

PRC2 is thought to be the histone methyltransferase (HMTase) responsible for H3‐K27
trimethylation at Polycomb target genes. Here we report the biochemical purification and …

The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq)
to examine the diversity of both antigen-specific and total B cells in healthy …

The Drosophila Polycomb group protein E(z) is a histone methyltransferase (HMTase) that
is essential for maintaining HOX gene silencing during development. E(z) exists in a …

Pygo and BCL9/Legless transduce the Wnt signal by promoting the transcriptional activity of
β-catenin/Armadillo in normal and malignant cells. We show that human and Drosophila …

The cytoplasmic messenger ribonucleoprotein particles of mammalian somatic cells contain
the protein YB-1, also called p50, as a major core component. YB-1 is multifunctional and …

Genomic information is selectively used to direct spatial and temporal gene expression
during differentiation. Interactions between topologically associating domains (TADs) and …

Transcriptional activation is controlled by chromatin, which needs to be unfolded and
remodeled to ensure access to the transcription start site (TSS). However, the mechanisms that …

Although it has been clearly established that well-positioned histone H2A.Z–containing
nucleosomes flank the nucleosome-depleted region (NDR) at the transcriptional start site (TSS) …

Ambient temperature affects plant growth and even minor changes can substantially impact
crop yields. The underlying mechanisms of temperature perception and response are just …