Wnt/β‐catenin signalling is central to development and its regulation is essential in preventing
cancer. Using phosphorylation of Dishevelled as readout of pathway activation, we …

Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key component of the
microprocessor complex, present strong differentiation defects. However, the exact reasons …

In mouse, although four Argonaute (AGO) proteins with partly overlapping functions in small-RNA
pathways exist, only Ago2 deficiency causes embryonic lethality. To investigate the …

A gene regulation network orchestrates processes ensuring the maintenance of cellular
identity and genome integrity. Small RNA s generated by the RNA se III DICER have emerged …

LINE‐1 (L1) retroelements have retained their ability to mobilize. Mechanisms regulating L1
mobility include DNA methylation in somatic cells and the piRNA pathway in the germline. …

MicroRNA (miRNA) loaded Argonaute (AGO) complexes regulate gene expression via
direct base pairing with their mRNA targets. Previous works suggest that up to 60% of …

Transposable elements (TEs) are mobile DNA elements that represent almost half of the
human genome. Transposition of TEs has been implicated as a source of genome evolution …

CRISPR/Cas9, originally discovered as a bacterial immune system, has recently been
engineered into the latest tool to successfully introduce site-specific mutations in a variety of …

Complex gene regulation systems ensure the maintenance of cellular identity during early
development in mammals. Eukaryotic small RNAs have emerged as critical players in RNA …

Long Interspersed Elements-1 (LINE-1 or L1) are a class of transposable elements which
account for almost 19 % of the mouse genome. This represents around 600,000 L1 fragments, …