Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
M Killer, J Wald, J Pieprzyk, TC Marlovits, C Löw - Science advances, 2021 - science.org
The uptake of peptides in mammals plays a crucial role in nutrition and inflammatory
diseases. This process is mediated by promiscuous transporters of the solute carrier family 15, …
diseases. This process is mediated by promiscuous transporters of the solute carrier family 15, …
[HTML][HTML] Molecular basis of TASL recruitment by the peptide/histidine transporter 1, PHT1
TF Custódio, M Killer, D Yu, V Puente… - Nature …, 2023 - nature.com
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate
immune responses. It can act as a receptor by recruiting the adaptor protein TASL which …
immune responses. It can act as a receptor by recruiting the adaptor protein TASL which …
[HTML][HTML] Differential complex formation via paralogs in the human Sin3 protein interaction network
Despite the continued analysis of HDAC inhibitors in clinical trials, the heterogeneous
nature of the protein complexes they target limits our understanding of the beneficial and off-target …
nature of the protein complexes they target limits our understanding of the beneficial and off-target …
[PDF][PDF] Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition
V Kotov, M Killer, KEJ Jungnickel, J Lei, G Finocchio… - Cell Reports, 2023 - cell.com
Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the
major facilitator superfamily that constitute the main route of entry for a wide range of dietary …
major facilitator superfamily that constitute the main route of entry for a wide range of dietary …
[HTML][HTML] Cryo-EM structure of an atypical proton-coupled peptide transporter: di-and tripeptide permease C
M Killer, G Finocchio, HDT Mertens… - Frontiers in molecular …, 2022 - frontiersin.org
Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS)
mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to …
mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to …
Molecular basis of TASL recruitment by PHT1
T Custódio, M Killer, D Yu, V Puente, D Teufel… - 2023 - researchsquare.com
PHT1 is a histidine/oligopeptide transporter with an essential role in Toll-like receptor innate
immune response. It can act as a receptor by recruiting the adaptor protein TASL which …
immune response. It can act as a receptor by recruiting the adaptor protein TASL which …
Purification and enzymatic assay of class I histone deacetylase enzymes
MK Adams, CAS Banks, S Miah, M Killer… - Methods in …, 2019 - Elsevier
The reversible acetylation of histones has a profound influence on transcriptional status.
Histone acetyltransferases catalyze the addition of these chemical modifications to histone …
Histone acetyltransferases catalyze the addition of these chemical modifications to histone …
[HTML][HTML] Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions
J Russick, PE Joubert, M Gillard-Bocquet… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through
their cytotoxic effector functions and their capacity to interact with other immune cells to …
their cytotoxic effector functions and their capacity to interact with other immune cells to …
[HTML][HTML] Crassostrea gigas mortality in France: the usual suspect, a herpes virus, may not be the killer in this polymicrobial opportunistic disease
B Petton, M Bruto, A James, Y Labreuche… - Frontiers in …, 2015 - frontiersin.org
Successive disease outbreaks in oyster (Crassostrea gigas) beds in France have resulted
in dramatic losses in production, and subsequent decline in the oyster-farming industry. …
in dramatic losses in production, and subsequent decline in the oyster-farming industry. …
Respiratory syncytial virus infects primary neonatal and adult natural killer cells and affects their antiviral effector function
EA van Erp, D Feyaerts, M Duijst… - The Journal of …, 2019 - academic.oup.com
Background Respiratory syncytial virus (RSV) is a major cause of severe acute lower
respiratory tract infections in infants. Natural killer (NK) cells are important antiviral effector cells …
respiratory tract infections in infants. Natural killer (NK) cells are important antiviral effector cells …