We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) …

Technical analysis is aimed at devising trading rules capable of exploiting short-term fluctuations
on the financial markets. Recent results indicate that this market timing approach may …

Purpose: Tumor somatic mutation analysis is part of the standard management of metastatic
lung cancer. However, physicians often have to deal with small biopsies and consequently …

Clinical mutation screening of the BRCA1 and BRCA2 genes for the presence of germline
inactivating mutations is used to identify individuals at elevated risk of breast and ovarian …

The susceptibility gene for ataxia telangiectasia, ATM, is also an intermediate-risk breast-cancer-susceptibility
gene. However, the spectrum and frequency distribution of ATM mutations …

Introduction The MRE11A-RAD50-Nibrin (MRN) complex plays several critical roles related
to repair of DNA double-strand breaks. Inherited mutations in the three components …

The abnormal regulation of amyloid-β (Aβ) metabolism (eg, production, cleavage, clearance)
plays a central role in Alzheimer’s disease (AD). Among endogenous factors believed to …

Introduction The COVID-19 outbreak in France is disturbing our health system. Urologists in
training who are already known to have burnout, are in the front line to face this disease. The …

Germline mutations in the PALB2 gene are associated with an increased risk of developing
breast cancer but little is known about the frequencies of rare variants in PALB2 and the …

Experimental models that recapitulate mutational landscapes of human cancers are needed
to decipher the rapidly expanding data on human somatic mutations. We demonstrate that …