[HTML][HTML] Determining structures of individual RNA conformers using atomic force microscopy images and deep neural networks
MFS Degenhardt, HF Degenhardt, YR Bhandari… - Research …, 2023 - ncbi.nlm.nih.gov
The vast percentage of the human genome is transcribed into RNA, many of which contain
various structural elements and are important for functions. RNA molecules are …
various structural elements and are important for functions. RNA molecules are …
[PDF][PDF] CALX-CBD1 Ca2+-binding cooperativity studied by NMR spectroscopy and ITC with Bayesian statistics
…, JD Rivera, PAM Vitale, MFS Degenhardt… - Biophysical …, 2020 - cell.com
The Na + /Ca 2+ exchanger of Drosophila melanogaster, CALX, is the main Ca 2+ -extrusion
mechanism in olfactory sensory neurons and photoreceptor cells. Na + /Ca 2+ exchangers …
mechanism in olfactory sensory neurons and photoreceptor cells. Na + /Ca 2+ exchangers …
Molecular structure and functional analysis of pyocin S8 from Pseudomonas aeruginosa reveals the essential requirement of a glutamate residue in the HNH motif for …
…, F Gomes, RM Domingos, MFS Degenhardt… - Journal of …, 2020 - Am Soc Microbiol
Multidrug resistance (MDR) is a serious threat to public health, making the development of
new antimicrobials an urgent necessity. Pyocins are protein antibiotics produced by …
new antimicrobials an urgent necessity. Pyocins are protein antibiotics produced by …
Structural and functional analysis of pyocin S8 from Pseudomonas aeruginosa : requirement of a glutamate in the HNH motif for the DNase activity
Multi-drug resistance (MDR) is a serious threat to global public health, making the development
of new antimicrobials an urgent necessity. Pyocins are protein antibiotics produced by …
of new antimicrobials an urgent necessity. Pyocins are protein antibiotics produced by …
[PDF][PDF] Molecular insights on CALX-CBD12 interdomain dynamics from MD simulations, RDCs, and SAXS
MF de Souza Degenhardt, PAM Vitale, LA Abiko… - Biophysical …, 2021 - cell.com
… First, energy minimization was performed during 2000 gradient steps, followed by heating
up the system from 100 K up to 300 K within 50 ps in three stages with 25,000 steps of 2 fs …
up the system from 100 K up to 300 K within 50 ps in three stages with 25,000 steps of 2 fs …
[HTML][HTML] Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
…, S Papiol, U Heilbronner, F Degenhardt… - Molecular …, 2023 - nature.com
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling
mental health disorder that affects about 1% of the population worldwide. Nevertheless, …
mental health disorder that affects about 1% of the population worldwide. Nevertheless, …
The genetics of the mood disorder spectrum: genome-wide association analyses of more than 185,000 cases and 439,000 controls
Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe, …
affect 10% to 20% of the population. They range from brief, mild episodes to severe, …
Characterisation of age and polarity at onset in bipolar disorder
…, N Dalkner, U Dannlowski, F Degenhardt… - The British Journal of …, 2021 - cambridge.org
Background Studying phenotypic and genetic characteristics of age at onset (AAO) and
polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and …
polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and …
Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study
…, AJ Forstner, U Heilbronner, F Degenhardt… - Bipolar …, 2019 - Wiley Online Library
Objectives Bipolar disorder (BD) with early disease onset is associated with an unfavorable
clinical outcome and constitutes a clinically and biologically homogenous subgroup within …
clinical outcome and constitutes a clinically and biologically homogenous subgroup within …
[HTML][HTML] Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated with depression
… We thank numerous people at Max Planck Institute, and all study sites in Germany and
Switzerland who contributed to this project. Controls were from the Dortmund Health Study, which …
Switzerland who contributed to this project. Controls were from the Dortmund Health Study, which …