A cellular census of human lungs identifies novel cell states in health and in asthma

…, CA Brandsma, W Timens, I Angelidis, M Strunz… - Nature medicine, 2019 - nature.com
Human lungs enable efficient gas exchange and form an interface with the environment, which
depends on mucosal immunity for protection against infectious agents. Tightly controlled …

[HTML][HTML] Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

M Strunz, LM Simon, M Ansari, JJ Kathiriya… - Nature …, 2020 - nature.com
The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, …

[HTML][HTML] Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

…, M Slyper, NP Smith, A Sountoulidis, M Strunz… - Nature medicine, 2021 - nature.com
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

[HTML][HTML] An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

I Angelidis, LM Simon, IE Fernandez, M Strunz… - Nature …, 2019 - nature.com
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are
the third leading cause of death worldwide. Here, we use single cell transcriptomics and …

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral …

…, M Slyper, N Smith, A Sountoulidis, M Strunz… - BioRxiv, 2020 - biorxiv.org
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

The human lung cell atlas: a high-resolution reference map of the human lung in health and disease

…, EL Rawlins, KB Meyer, M Strunz… - American journal of …, 2019 - atsjournals.org
Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung
cell types in health and disease is currently revolutionizing the identification of disease …

[HTML][HTML] The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

…, M Ansari, M Novikova, D Jiang, M Strunz… - Nature …, 2022 - nature.com
Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological
process, which requires rapid responses via post translational modifications (PTM) of …

Deep proteome profiling reveals common prevalence of MZB1-positive plasma B cells in human lung and skin fibrosis

…, CH Mayr, G Leuschner, M Strunz… - American journal of …, 2017 - atsjournals.org
Rationale: Analyzing the molecular heterogeneity of different forms of organ fibrosis may
reveal common and specific factors and thus identify potential future therapeutic targets. …

Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers

…, PE Geyer, I Angelidis, M Strunz… - EMBO molecular …, 2021 - embopress.org
The correspondence of cell state changes in diseased organs to peripheral protein signatures
is currently unknown. Here, we generated and integrated single‐cell transcriptomic and …

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

…, Y Hu, Z Ertüz, MA Lopez, M Ansari, M Strunz… - Nature, 2020 - nature.com
Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the
development of tertiary lymphoid structures 1 , 2 , which are associated with severe chronic …