Cell-to-cell communication can be inferred from ligand–receptor expression in cell
transcriptomic datasets. However, important challenges remain: global integration of cell-to-cell …

T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh
polarization pathways have been thus far associated with Th1 and Th17 polarization pathways. …

The RNF43_p.G659fs mutation occurs frequently in colorectal cancer, but its function remains
poorly understood and there are no specific therapies directed against this alteration. In …

Computational modeling constitutes a crucial step toward the functional understanding of
complex cellular networks. In particular, logical modeling has proven suitable for the dynamical …

Purpose: While patients responding to checkpoint blockade often achieve remarkable
clinical responses, there is still significant unmet need due to resistant or refractory tumors. A …

The ontogeny of human Langerhans cells (LCs) remains poorly characterized, in particular
the nature of LC precursors and the factors that may drive LC differentiation. Here we report …

Dendritic cells (DC) are traditionally classified according to their ontogeny and their ability to
induce T cell response to antigens, however, the phenotypic and functional state of these …

The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo
pathway, which regulates tissue homeostasis, organ size, regeneration, and tumorigenesis. …

This study was funded in part by a grant from the German Cystic Fibrosis Association
Mukoviszidose eV (grant no. 1705). MO is a postdoctoral researcher funded by the Biotechnology …

Cell-cell communication involves a large number of molecular signals that function as words
of a complex language whose grammar remains mostly unknown. Here, we describe an …