Polylactide degradation activates immune cells by metabolic reprogramming

…, JM Hix, CL Mallett, SJ Chung, M Hakun… - Advanced …, 2023 - Wiley Online Library
Polylactide (PLA) is the most widely utilized biopolymer in medicine. However, chronic
inflammation and excessive fibrosis resulting from its degradation remain significant obstacles to …

Glycolytic reprogramming underlies immune cell activation by polyethylene wear particles

CV Maduka, OM Habeeb, MM Kuhnert, M Hakun… - Biomaterials …, 2023 - Elsevier
Primary total joint arthroplasties (TJAs) are widely and successfully applied reconstructive
procedures to treat end-stage arthritis. Nearly 50 % of TJAs are now performed in young …

Stem cell therapy of myocardial infarction: a promising opportunity in bioengineering

B Jiang, L Yan, JG Shamul, M Hakun… - Advanced …, 2020 - Wiley Online Library
Myocardial infarction (MI) is a life‐threatening disease resulting from the irreversible death of
cardiomyocytes (CMs). Stem cell‐based therapies have been studied for MI treatment over …

[HTML][HTML] Challenges and opportunities in NUT carcinoma research

B Gu, MC Hakun - Genes, 2021 - mdpi.com
NUT carcinoma (NC) is a type of aggressive cancer driven by chromosome translocations.
Fusion genes between a DNA-binding protein, such as bromodomain and extraterminal …

The generation of a Nutm1 knock-in reporter mouse line for imaging post-meiotic spermatogenesis

M Hakun, J Rossant, B Gu - bioRxiv, 2022 - biorxiv.org
Spermiogenesis, the post-meiotic stage of sperm development, is critical for normal male
fertility. Many genetic defects and environmental assaults that affect spermiogenesis have been …

[BOOK][B] Immune Cell Metabolism: A Pivot in Tissue Engineering

CV Maduka - 2022 - search.proquest.com
Chapter 1 introduces emerging concepts in tissue engineering as well as the dynamic
metabolism of immune cells, both of which underlie the motivation for my dissertation. Central to …

[HTML][HTML] Designing a 3D printing based auxetic cardiac patch with hiPSC-CMs for heart repair

…, JH Park, HJ Park, S Bheri, JT Maxwell… - Journal of …, 2021 - mdpi.com
Myocardial infarction is one of the largest contributors to cardiovascular disease and reduces
the ability of the heart to pump blood. One promising therapeutic approach to address the …

Engineered heart slice model of arrhythmogenic cardiomyopathy using plakophilin-2 mutant myocytes

A Blazeski, J Lowenthal, Y Wang, R Teuben… - … Engineering Part A, 2019 - liebertpub.com
Arrhythmogenic cardiomyopathy (AC), a cause of sudden cardiac death among young and
otherwise healthy individuals, is a heritable disease that can be modeled in vitro using patient…

[BOOK][B] Calendar of the Close Rolls Preserved in the Pulic Record Ofice: 1339-1341

HCM Lyte - 1901 - books.google.com
… a sack to be allowed to Geoffrey Hakun of Northcave, of his wool taken out of that port when
the passage of wool is open to all, or when he has special licence from the king, until 641. 9s…

Functional magnetic resonance imaging of mild traumatic brain injury

AR Mayer, PSF Bellgowan, FM Hanlon - Neuroscience & Biobehavioral …, 2015 - Elsevier
Functional magnetic resonance imaging (fMRI) offers great promise for elucidating the
neuropathology associated with a single or repetitive mild traumatic brain injury (mTBI). The …