User profiles for Maya Deshmukh
 | Maya G. DeshmukhMD/PhD student, Yale University Verified email at umich.edu Cited by 690 |
[PDF][PDF] Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease
There is a clinical need for direct-acting antivirals targeting SARS-CoV-2, the coronavirus
responsible for the COVID-19 pandemic, to complement current therapeutic strategies. The …
responsible for the COVID-19 pandemic, to complement current therapeutic strategies. The …
Potent noncovalent inhibitors of the main protease of SARS-CoV-2 from molecular sculpting of the drug perampanel guided by free energy perturbation calculations
Starting from our previous finding of 14 known drugs as inhibitors of the main protease (M
pro ) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak hit …
pro ) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak hit …
[HTML][HTML] Structural insights into curli CsgA cross-β fibril architecture inspire repurposing of anti-amyloid compounds as anti-biofilm agents
…, N Golan, E Tayeb-Fligelman, M Deshmukh… - PLoS …, 2019 - journals.plos.org
Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute
to biofilm formation, thereby promoting bacterial resistance to environmental stressors. …
to biofilm formation, thereby promoting bacterial resistance to environmental stressors. …
Identification of 14 known drugs as inhibitors of the main protease of SARS-CoV-2
…, J Tirado-Rives, M Deshmukh… - ACS medicinal …, 2020 - ACS Publications
A consensus virtual screening protocol has been applied to ca. 2000 approved drugs to seek
inhibitors of the main protease (M pro ) of SARS-CoV-2, the virus responsible for COVID-19…
inhibitors of the main protease (M pro ) of SARS-CoV-2, the virus responsible for COVID-19…
Optimization of triarylpyridinone inhibitors of the main protease of SARS-CoV-2 to low-nanomolar antiviral potency
…, JA Ippolito, ME Liosi, MG Deshmukh… - ACS Medicinal …, 2021 - ACS Publications
Non-covalent inhibitors of the main protease (M pro ) of SARS-CoV-2 having a pyridinone
core were previously reported with IC 50 values as low as 0.018 μM for inhibition of enzymatic …
core were previously reported with IC 50 values as low as 0.018 μM for inhibition of enzymatic …
Amyloid by design: intrinsic regulation of microbial amyloid assembly
The term amyloid has historically been used to describe fibrillar aggregates formed as the
result of protein misfolding and that are associated with a range of diseases broadly termed …
result of protein misfolding and that are associated with a range of diseases broadly termed …
[HTML][HTML] The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation
…, A Beaussart, A Kikhney, M Deshmukh… - Scientific Reports, 2016 - nature.com
The major human pathogen Streptococcus pneumoniae is a leading cause of disease and
death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term …
death worldwide. Pneumococcal biofilm formation within the nasopharynx leads to long-term …
[HTML][HTML] Hox cluster duplication in the basal teleost Hiodon alosoides (Osteoglossomorpha)
…, R McDaniell, JD Raincrow, M Deshmukh… - Theory in …, 2009 - Springer
Large-scale—even genome-wide—duplications have repeatedly been invoked as an explanation
for major radiations. Teleosts, the most species-rich vertebrate clade, underwent a “fish…
for major radiations. Teleosts, the most species-rich vertebrate clade, underwent a “fish…
Longitudinal Remodeling in Persistent Heart Failure With Reduced Ejection Fraction and Improved Ejection Fraction
…, A Baltodano, D Patel, C Sellers-Porter, M Deshmukh… - Circulation, 2023 - Am Heart Assoc
Background: Among patients with heart failure (HF) with reduced ejection fraction (HFrEF),
a subpopulation improves ventricular function, HF with improved ejection fraction (HFimpEF). …
a subpopulation improves ventricular function, HF with improved ejection fraction (HFimpEF). …
THE RISK OF DEMENTIA AMONG INDIVIDUALS WITH DEPRESSION AFTER A TRAUMATIC BRAIN INJURY
J Ashby, M Nuno, B Ugiliweneza, M Deshmukh… - Innovation in …, 2022 - ncbi.nlm.nih.gov
Although traumatic brain injury (TBI) has been found to be associated with dementia and
depression, large‐scale studies of US non‐Veteran populations are limited. This study …
depression, large‐scale studies of US non‐Veteran populations are limited. This study …