Bacteria were first detected in human tumors more than 100 years ago, but the characterization
of the tumor microbiome has remained challenging because of its low biomass. We …

Elevated postprandial blood glucose levels constitute a global epidemic and a major risk
factor for prediabetes and type II diabetes, but existing dietary methods for controlling them …

Human gut microbiome composition is shaped by multiple factors but the relative contribution
of host genetics remains elusive. Here we examine genotype and microbiome data from …

A variety of species of bacteria are known to colonize human tumours 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8
, 9 , 10 – 11 , proliferate within them and modulate immune function, which ultimately affects …

The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …

Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused
by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of …

Bread is consumed daily by billions of people, yet evidence regarding its clinical effects is
contradicting. Here, we performed a randomized crossover trial of two 1-week-long dietary …

Differences in the presence of even a few genes between otherwise identical bacterial
strains may result in critical phenotypic differences. Here we systematically identify microbial …

Understanding how precise control of gene expression is specified within regulatory DNA
sequences is a key challenge with far-reaching implications. Many studies have focused on …

The TP53 gene is frequently mutated in human cancer. Research has focused predominantly
on six major "hotspot" codons, which account for only ∼30% of cancer-associated p53 …