Asymmetric cell division (ACD) produces two daughter cells with distinct fates or characteristics.
Many adult stem cells use ACD as a means of maintaining stem cell number and thus …

In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have
emerged as a novel mechanism of intercellular communication. Protrusion-based cellular …

Information exchange between different cells makes multicellular life possible. Signaling
between cells can occur over long distances, as in the case of hormone signaling, or it can take …

Stem cell niches provide resident stem cells with signals that specify their identity. Niche
signals act over a short range such that only stem cells but not their differentiating progeny …

Many adult stem cells reside in a special microenvironment known as the niche, where they
receive essential signals that specify stem cell identity. Cell-cell adhesion mediated by …

The piRNA pathway plays an important role in maintaining genome stability in the germ line
by silencing transposable elements (TEs) from fly to mammals. As a highly conserved …

10.7554/eLife.04960.001 Many stem cells divide asymmetrically in order to balance self-renewal
with differentiation. The essence of asymmetric cell division (ACD) is the polarization of …

Tight regulation of stem cell proliferation is fundamental to tissue homeostasis, aging and
tumor suppression. Although stem cells are characterized by their high potential to proliferate …

10.7554/eLife.20977.001 Asymmetric stem cell division is often accompanied by stereotypical
inheritance of the mother and daughter centrosomes. However, it remains unknown …

Stem cells divide asymmetrically to generate a stem cell and a differentiating daughter cell.
Yet, it remains poorly understood how a stem cell and a differentiating daughter cell can …