The overwhelming majority of participants in current genetic studies are of European ancestry.
To elucidate disease biology in the East Asian population, we conducted a genome-wide …

Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for this …

Background The response to treatment for asthma is characterized by wide interindividual
variability, with a significant number of patients who have no response. We hypothesized that …

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic
and environmental factors 1 , 2 . Through a genome-wide association study and a replication …

Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic
and environmental factors. On the basis of data from a genome-wide association study (GWAS…

… Correspondence and requests for reprints should be addressed to Mayumi Tamari, MD,
Ph.D., Laboratory for Respiratory Diseases, Center for Genomic Medicine, Institute of Physical …

Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, …

BACKGROUND: NLR family, pyrin domain containing 3 (NLRP3), controls the activity of
inflammatory caspase-1 by forming inflammasomes, which leads to cleavage of the procytokines …

Atopic dermatitis is a common inflammatory skin disease with a strong heritable component.
Pathogenetic models consider keratinocyte differentiation defects and immune alterations …

Atopic dermatitis (AD) is a common inflammatory skin disease associated with the local
infiltration of T helper type 2 (Th2) cells. The ST2 gene encodes both membrane-bound ST2L …