User profiles for Mazhar Adli
 | Mazhar AdliNorthwestern University Verified email at northwestern.edu Cited by 20558 |
[HTML][HTML] The CRISPR tool kit for genome editing and beyond
M Adli - Nature communications, 2018 - nature.com
CRISPR is becoming an indispensable tool in biological research. Once known as the
bacterial immune system against invading viruses, the programmable capacity of the Cas9 …
bacterial immune system against invading viruses, the programmable capacity of the Cas9 …
CRISPR ethics: moral considerations for applications of a powerful tool
C Brokowski, M Adli - Journal of molecular biology, 2019 - Elsevier
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …
Adenomyosis pathogenesis: insights from next-generation sequencing
BACKGROUND Adenomyosis, characterized by the presence of islands of endometrial tissue
surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the most …
surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the most …
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
O Abdel-Wahab, J Gao, M Adli, A Dey… - Journal of Experimental …, 2013 - rupress.org
Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10–30% of patients with
myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are …
myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are …
[HTML][HTML] Initial genome sequencing and analysis of multiple myeloma
…, CL Harview, JP Brunet, GJ Ahmann, M Adli… - Nature, 2011 - nature.com
Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly
understood. Here we report the massively parallel sequencing of 38 tumour genomes and …
understood. Here we report the massively parallel sequencing of 38 tumour genomes and …
[HTML][HTML] Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3
lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications …
lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications …
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
RNA-guided genome editing with the CRISPR-Cas9 system has great potential for basic
and clinical research, but the determinants of targeting specificity and the extent of off-target …
and clinical research, but the determinants of targeting specificity and the extent of off-target …
[PDF][PDF] ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome,
myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse …
myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse …
[HTML][HTML] Genome-wide chromatin state transitions associated with developmental and environmental cues
Differences in chromatin organization are key to the multiplicity of cell states that arise from
a single genetic background, yet the landscapes of in vivo tissues remain largely uncharted. …
a single genetic background, yet the landscapes of in vivo tissues remain largely uncharted. …
[PDF][PDF] Using whole-exome sequencing to identify inherited causes of autism
Despite significant heritability of autism spectrum disorders (ASDs), their extreme genetic
heterogeneity has proven challenging for gene discovery. Studies of primarily simplex families …
heterogeneity has proven challenging for gene discovery. Studies of primarily simplex families …