Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in
the pathogenesis of prion diseases. In the dominantly inherited prion protein amyloidosis …

Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there
is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau …

In human neurodegenerative diseases associated with the intracellular aggregation of Tau
protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau …

In neurodegenerative diseases and aging, the microtubuleassociated protein tau (MAPT)
and the transmembrane lysosomal protein 106B (TMEM106B) become misfolded in different …

Recent progress in the development of affinity grids for cryoelectron microscopy (cryo-EM)
typically employs genetic engineering of the protein sample such as histidine or Spy tagging, …

Even with implementation of current influenza vaccines, influenza still claims up to 500,000
lives worldwide annually, indicating a need for a better vaccine strategy. We have developed …

Eight Schiff bases have been synthesized by conventional and three different eco-friendly
methods, whereby two aromatic carbonyl compounds viz. 2-thiophenecarboxaldehyde and …

Eight novel Schiff Bases, from 6,6′-diformyl-2,2′-bipyridyl (1a, 43%)with O, N, S and F
containing amines: Thiosemicarbazide (2a, 70%), 4-Ethyl-3-thiosemicabazide (2b, 75%), 4,4-…

Design and synthesis of organic chelating agents containing nitrogen and sulfur as donor
atoms and their metal complexes is an interesting field of research for their different types of …

The paper deals to minimize the water crisis of a drought prone area in Bangladesh. In this
research an alternative and low-cost effective cultivation method has been developed. In the …