The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

X-chromosome inactivation (XCI) achieves dosage compensation between males and females
through the silencing of the majority of genes on one of the female X chromosomes. Thus…

Tissue differences are one of the largest contributors to variability in the human DNA
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of human …

The development of biological markers of aging has primarily focused on adult samples.
Epigenetic clocks are a promising tool for measuring biological age that show impressive …

Background Prenatal alcohol exposure is the leading preventable cause of behavioral and
cognitive deficits, which may affect between 2 and 5 % of children in North America. While …

Background Confounding due to cellular heterogeneity represents one of the foremost
challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods …

Background DNA methylation is an epigenetic mark that balances plasticity with stability.
While DNA methylation exhibits tissue specificity, it can also vary with age and potentially …

Background Allergic disease affects 30% to 40% of the world's population, and its development
is determined by the interplay between environmental and inherited factors. Air pollution, …

Chronic inflammation contributes to a wide range of human diseases, and environments in
infancy and childhood are important determinants of inflammatory phenotypes. The …

Internationally adopted adolescents who are adopted as young children from conditions of
poverty and deprivation have poorer physical and mental health outcomes than do …