There are fundamental similarities between sleep in mammals and quiescence in the arthropod
Drosophila melanogaster, suggesting that sleep-like states are evolutionarily ancient 1 , …

Vulva1 induction in C. elegans is controlled by a highly conserved signaling pathway similar
to the RTK-Ras-MAPKcascade in mammals. By screening for suppressors of the Multivulva …

Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are
used repeatedly during metazoan development to control many different biological processes…

Genetic screens for modifiers of activated Ras phenotypes have identified a novel protein,
kinase suppressor of Ras (KSR), which shares significant sequence homology with Raf family …

The lin-12 gene of Caenorhabditis elegans is thought to encode a receptor which mediates
cell-cell interactions required to specify certain cell fates. Reversion of the egg-laying …

The Ras and Notch signaling pathways are used over and over again during development
to control many different biological processes. Frequently, these two signaling pathways …

… Meera Sundaram is a graduate student in computer engineering at San Jose State …
Sundaram received a BS in chemical engineering from Bangalore University, India. She is a …

The excretory system of the nematode Caenorhabditis elegans is a superb model of tubular
organogenesis involving a minimum of cells. The system consists of just three unicellular …

Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK) signaling
pathways control many aspects of C. elegans development and behavior. Studies in C. …

Kinase Suppressor of Ras (KSR) is a conserved protein that positively regulates Ras signaling
and may function as a scaffold for Raf, MEK, and ERK [1]. However, the precise role of …