… 144 See, eg, letter from Philip Lynch, Director, Human Rights Law Resource Centre and
Megan Davis, Director, Indigenous Law Centre, to the Honourable Kevin Rudd MP, 16 May …

Tolerance to self-antigens prevents the elimination of cancer by the immune system 1 , 2 .
We used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance …

INTRODUCTION Most cancers are recognized and attacked by the immune system but can
progress owing to tumor-mediated immunosuppression and immune evasion mechanisms. …

The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated
potential for treatment of various cancers 1 , 2 , 3 , 4 , 5 , 6 – 7 . However, little is known …

Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly
in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the …

BACKGROUND. CAR T cells are a promising therapy for hematologic malignancies. B cell
maturation antigen (BCMA) is a rational target in multiple myeloma (MM). METHODS. We …

Chimeric antigen receptors (CAR) are synthetic molecules that provide new specificities to T
cells. Although successful in treatment of hematologic malignancies, CAR T cells are …

People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink
in social settings, yet the effect of alcohol on human brain circuits involved in reward and …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

The success of chimeric antigen receptor (CAR)–mediated immunotherapy in acute
lymphoblastic leukemia (ALL) highlights the potential of T-cell therapies with directed cytotoxicity …