User profiles for Megan K Oliva

megan k oliva

The Florey Institute of Neuroscience
Verified email at florey.edu.au
Cited by 380

Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms of SCN2A epilepsy

…, YH Deerasooriya, MR Cilio, MK Oliva… - Proceedings of the …, 2018 - National Acad Sciences
De novo variants in SCN2A developmental and epileptic encephalopathy (DEE) show
distinctive genotype–phenotype correlations. The two most recurrent SCN2A variants in DEE, …

Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics

JJ Pérez-Moreno, RC Smith, MK Oliva, F Gallo… - Journal of Cell …, 2023 - rupress.org
Neuronal endoplasmic reticulum (ER) appears continuous throughout the cell. Its shape and
continuity are influenced by ER-shaping proteins, mutations in which can cause distal axon …

Rapid release of Ca2+ from endoplasmic reticulum mediated by Na+/Ca2+ exchange

CH Liu, Z Chen, MK Oliva, J Luo, S Collier… - Journal of …, 2020 - Soc Neuroscience
Phototransduction in Drosophila is mediated by phospholipase C (PLC) and Ca 2+ -permeable
TRP channels, but the function of endoplasmic reticulum (ER) Ca 2+ stores in this …

[HTML][HTML] Endoplasmic reticulum lumenal indicators in Drosophila reveal effects of HSP-related mutations on endoplasmic reticulum calcium dynamics

MK Oliva, JJ Pérez-Moreno, J O'Shaughnessy… - Frontiers in …, 2020 - frontiersin.org
Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly
mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms …

Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics

MK Oliva, JJ Perez-Moreno, J O'Shaughnessy… - bioRxiv, 2020 - biorxiv.org
Genes for ER-shaping proteins are among the most commonly mutated in Hereditary Spastic
Paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of …

Research data supporting" Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics"

…, RC Smith, MK Oliva, F Gallo, S Ojha, K Müller… - 2023 - repository.cam.ac.uk
Oliva, Megan K … This work was supported by grants from the Medical Research Council
(MRC) (MR/S011226/1), the Biotechnology and Biological Sciences Research Council …

Research data supporting" Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium …

MK Oliva, J Perez Moreno, J O'Shaughnessy… - 2020 - repository.cam.ac.uk
Fig 2-Main folder-R files for Figs 2, 3, 4 analyses A-Organised as Fig 1 folders B-3 tif timecourses
for CEPIA; 3 tif timecourses for GCaMP210ER. Of each group of 3, one is original, one …

A multicenter study assessing survival in patients with metastatic renal cell carcinoma receiving immune checkpoint inhibitor therapy with and without cytoreductive …

…, E Trott, SK Holt, ER Dwyer, J Kramer, K Oliva… - … Oncology: Seminars and …, 2023 - Elsevier
Background Cytoreductive nephrectomy (CN) for the treatment of metastatic renal cell carcinoma
(mRCC) was called into question following the publication of the CARMENA trial. While …

Proteomic analysis and characterisation of human cervico‐vaginal fluid proteins

MKW Di Quinzio, K Oliva, SJ Holdsworth… - Australian and New …, 2007 - Wiley Online Library
Aim: Cervico‐vaginal fluid (CVF) may provide insight into the biochemical pathways of human
reproduction and parturition. The aim of this study was to establish a 2‐D electrophoretic …

[HTML][HTML] Incorporating digitally derived endpoints within clinical development programs by leveraging prior work

…, MK Doyle, D Friend, R Kalamegham, L Oliva… - NPJ Digital …, 2023 - nature.com
Digital health technologies (DHTs) enable remote data collection, support a patient-centric
approach to drug development, and provide real-time data in real-world settings. With …