Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by
scarring of the lung that is believed to result from an atypical response to injury of the …

Background The role of copy number variants (CNVs) in susceptibility to asthma is not well
understood. This is, in part, due to the difficulty of accurately measuring CNVs in large …

Background Chronic sputum production impacts on quality of life and is a feature of many
respiratory diseases. Identification of the genetic variants associated with chronic sputum …

Reduced lung function predicts mortality and is key to the diagnosis of COPD. In a genome-wide
association study in 400,102 individuals of European ancestry, we define 279 lung …

Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by
progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the …

Background Sepsis is a severe systemic inflammatory response to infections that is accompanied
by organ dysfunction and has a high mortality rate in adult intensive care units. Most …

3. In the Fig. 3b table, the SPIROMICS row:“1.54, 1.38, 1.72, 4.47× 10–14, 988, 537”, should
be “1.55, 1.39, 1.74, 6.80× 10–14, 973, 526”; and the Meta-analysis row:“1.55, 1.48, 1.62, …

Idiopathic Pulmonary Fibrosis (IPF) is a rare lung disease characterised by inflammation and
scarring of the alveoli. Although genetic and environmental factors have been reported in …

Introduction: Sepsis is a severe inflammatory response to infections with a high death rate.
We previously conducted the first GWAS of copy number variations in 839 sepsis cases from …