User profiles for Megan L. Settell

Megan L. Settell

University of Wisconsin - Madison
Verified email at wisc.edu
Cited by 596

[HTML][HTML] A diamond-based electrode for detection of neurochemicals in the human brain

…, FS Manciu, MP Marsh, SB Paek, ML Settell… - Frontiers in human …, 2016 - frontiersin.org
Deep brain stimulation (DBS), a surgical technique to treat certain neurologic and psychiatric
conditions, relies on pre-determined stimulation parameters in an open-loop configuration. …

Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation

ML Settell, NA Pelot, BE Knudsen… - Journal of neural …, 2020 - iopscience.iop.org
Objective. Given current clinical interest in vagus nerve stimulation (VNS), there are surprisingly
few studies characterizing the anatomy of the vagus nerve in large animal models as it …

[HTML][HTML] Functional circuitry effect of ventral tegmental area deep brain stimulation: imaging and neurochemical evidence of mesocortical and mesolimbic pathway …

ML Settell, P Testini, S Cho, JH Lee, CD Blaha… - Frontiers in …, 2017 - frontiersin.org
Background: The ventral tegmental area (VTA), containing mesolimbic and mesocortical
dopaminergic neurons, is implicated in processes involving reward, addiction, reinforcement, …

Brain structure and cognition 3 years after the end of an early menopausal hormone therapy trial

…, JA Fields, JL Gunter, ML Senjem, ML Settell… - Neurology, 2018 - AAN Enterprises
Objective The effects of 2 frequently used formulations of menopausal hormone therapy (mHT)
on brain structure and cognition were investigated 3 years after the end of a randomized, …

Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect

SL Blanz, ED Musselman, ML Settell… - Journal of Neural …, 2023 - iopscience.iop.org
Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-approved
for the treatment of drug-resistant epilepsy, treatment-resistant depression, and …

[HTML][HTML] Sources of off-target effects of vagus nerve stimulation using the helical clinical lead in domestic pigs

EN Nicolai, ML Settell, BE Knudsen… - Journal of neural …, 2020 - iopscience.iop.org
Objective Clinical data suggest that efficacious vagus nerve stimulation (VNS) is limited by
side effects such as cough and dyspnea that have stimulation thresholds lower than those for …

An injectable neural stimulation electrode made from an in‐body curing polymer/metal composite

…, BA Gosink, AJ Asp, ML Settell… - Advanced …, 2019 - Wiley Online Library
Implanted neural stimulation and recording devices hold vast potential to treat a variety of
neurological conditions, but the invasiveness, complexity, and cost of the implantation …

Dopamine release in the nonhuman primate caudate and putamen depends upon site of stimulation in the subthalamic nucleus

HK Min, EK Ross, HJ Jo, S Cho, ML Settell… - Journal of …, 2016 - Soc Neuroscience
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for
medically refractory Parkinson's disease. Although DBS has recognized clinical utility, its …

[HTML][HTML] Clinically-derived vagus nerve stimulation enhances cerebrospinal fluid penetrance

…, JA Pisaniello, JP Ness, E Ross, EN Nicolai, ML Settell… - Brain Stimulation, 2020 - Elsevier
Introduction Vagus nerve stimulation (VNS) is an FDA-approved neuromodulatory treatment
used in the clinic today for epilepsy, depression, and cluster headaches. Moreover, …

Fornix deep brain stimulation circuit effect is dependent on major excitatory transmission via the nucleus accumbens

EK Ross, JP Kim, ML Settell, SR Han, CD Blaha… - Neuroimage, 2016 - Elsevier
Introduction Deep brain stimulation (DBS) is a circuit-based treatment shown to relieve
symptoms from multiple neurologic and neuropsychiatric disorders. In order to treat the memory …