Background High-density lipoprotein (HDL) may provide cardiovascular protection by promoting
reverse cholesterol transport from macrophages. We hypothesized that the capacity of …

Background Although HDL cholesterol concentrations are strongly and inversely associated
with risk of coronary heart disease, interventions that raise HDL cholesterol do not reduce …

A major goal of biomedicine is to understand the function of every gene in the human genome
1 . Loss-of-function mutations can disrupt both copies of a given gene in humans and …

Background : Although epidemiological studies have reported positive associations
between circulating urate levels and cardiometabolic diseases, causality remains uncertain. …

Objectives : This study sought to examine the role of lipoprotein-associated phospholipase
A 2 (Lp-PLA 2 /PLA2G7) in human inflammation and coronary atherosclerosis. Background : …

OBJECTIVE: Postprandial triglyceridemia predicts cardiovascular events. Niacin might lower
postprandial triglycerides by restricting free fatty acids. Immediate-release niacin reduced …

A major goal of biomedicine is to understand the function of every gene in the human
genome. Null mutations can disrupt both copies of a given gene in humans and phenotypic …

Background: Although plasma HDL-C levels are strongly associated with risk of coronary heart
disease (CHD), interventions that raise HDL-C have not been shown to reduce CHD risk. …

Niacin has been used for decades as a lipid lowering agent but its use is limited by flushing.
Stimulation of a G-protein coupled receptor (GPR109A) on immune cells of the skin by …

Background: Familial hypercholesterolemia (FH) is a common heritable disorder of elevated
low density lipoprotein cholesterol (LDL-C) with an estimated prevalence of 1/200-300 in …