Brain aging is marked by structural, chemical, and genetic changes leading to cognitive
decline and impaired neural functioning. Further, aging itself is also a risk factor for a number of …

Gangliosides have been shown to be necessary for β-amyloid (Aβ) binding and aggregation.
GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, …

A simultaneous increase in cytosolic Zn 2+ and Ca 2+ accompanies the initiation of neuronal
cell death signaling cascades. However, the molecular convergence points of cellular …

While the onset and extent of epilepsy increases in the aged population, the reasons for this
increased incidence remain unexplored. The present study used two inbred strains of mice (…

Consumption of a diet that significantly elevates homocysteine (homocysteinemia) induces
cell death in the CA3 hippocampal subfield in amyloid precursor protein (APP) over-…

Key points K + efflux through newly membrane‐inserted voltage‐gated Kv2.1 K + channels
precedes neuronal apoptosis. In this study, we show that the binding site of the soluble N‐…

Caspase activity during apoptosis is inhibited by physiological concentrations of intracellular
K + . To enable apoptosis in injured cortical and hippocampal neurons, cellular loss of this …

Methamphetamine is a drug of abuse that can induce oxidative stress and neurotoxicity to
dopaminergic neurons. We have previously reported that oxidative stress promotes the …

In July 2020, four months into the disruption of normal life caused by the Covid-19 pandemic,
we assessed the institutional climate within the School of Medicine. Voluntary surveys were …

In July 2020, four months into the disruption of normal life caused by the Covid-19 pandemic,
we assessed the institutional climate within the School of Medicine. Voluntary surveys were …