DNA vaccine protection against SARS-CoV-2 in rhesus macaques
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top …
syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top …
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
…, FJN Lelis, S Henson, DR Monaco, M Travers… - Science, 2020 - science.org
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This analysis …
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This analysis …
[PDF][PDF] Quick COVID-19 healers sustain anti-SARS-CoV-2 antibody production
…, A Zuiani, S Fischinger, J Mullur, C Atyeo, M Travers… - Cell, 2020 - cell.com
Antibodies are key immune effectors that confer protection against pathogenic threats. The
nature and longevity of the antibody response to SARS-CoV-2 infection are not well defined. …
nature and longevity of the antibody response to SARS-CoV-2 infection are not well defined. …
Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
…, H Li, LM Murphy, ME Travers… - Proceedings of the …, 2017 - National Acad Sciences
Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet
need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an …
need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an …
[PDF][PDF] Targeting CDK9 reactivates epigenetically silenced genes in cancer
Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through RNAPII
pause release. We now report that CDK9 is also essential for maintaining gene silencing at …
pause release. We now report that CDK9 is also essential for maintaining gene silencing at …
[PDF][PDF] Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike
Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2
infections, but with unknown reach from original infection to antigenically drifted variants. We …
infections, but with unknown reach from original infection to antigenically drifted variants. We …
DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer
M Travers, SM Brown, M Dunworth, CE Holbert… - Cancer research, 2019 - AACR
Combined epigenetic and polyamine-reducing therapy stimulates M1 macrophage
polarization in the tumor microenvironment of an ovarian cancer mouse model, resulting in …
polarization in the tumor microenvironment of an ovarian cancer mouse model, resulting in …
[HTML][HTML] Serum extracellular vesicle depletion processes affect release and infectivity of HIV-1 in culture
Extracellular vesicles (EVs) are involved in intercellular communication and affect processes
including immune and antiviral responses. Blood serum, a common cell culture medium …
including immune and antiviral responses. Blood serum, a common cell culture medium …
The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide
…, C Kramer, BS Leifer, E Nash, MH Qi, M Travers… - … /Genetic Toxicology and …, 2019 - Elsevier
DNA damage is ubiquitous and can arise from endogenous or exogenous sources. DNA-damaging
alkylating agents are present in environmental toxicants as well as in cancer …
alkylating agents are present in environmental toxicants as well as in cancer …
Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic
…, H Li, LM Murphy, ME Travers… - Proceedings of the …, 2018 - National Acad Sciences
In the letter by Haffner et al.(1), they report that seminoma cell-intrinsic DNA hypomethylation
is associated with endogenous retroviral expression, an IFN response, and lymphocytic …
is associated with endogenous retroviral expression, an IFN response, and lymphocytic …