SNCA, the first gene associated with Parkinson’s disease, encodes the α-synuclein protein,
the predominant component within pathological inclusions termed Lewy bodies. The …

Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-onset
Parkinson’s disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial quality …

One of the hallmarks of Alzheimer's disease (AD) pathogenesis is believed to be the production
and deposition of amyloid-beta (Aβ) peptide into extracellular plaques. Existing research …

By providing a three-dimensional in vitro culture system with key features of the substantia
nigra region in the brain, 3D neuronal organoids derived from human induced pluripotent …

The development of brain organoids represents a major technological advance in the stem
cell field, a novel bridge between traditional 2D cultures and in vivo animal models. In …

Patient-derived organoids from induced pluripotent stem cells have emerged as a model for
studying human diseases beyond conventional two-dimensional (2D) cell culture. Briefly, …

Parkinson's disease is a devastating neurodegenerative disorder characterized by loss of
neuromelanin‐containing dopaminergic neurons. Novel 3D culture systems like human …

Silver is ingested in India in the form of varak, Ayurvedic bhasm and water contained in silver
utensils, but nobody knows their effects. We have examined the effect of interaction of silver …

Social democracy demands existence of freedom, equality, justice and solidarity among
masses. Doyens like John Locke, Jean Jacques Rousseau and Karl Marx decrypted the social …

Motivated by the growing number of single cell RNA sequencing datasets (scRNAseq)
revealing the cellular heterogeneity in complex tissues, particularly in brain and induced …