User profiles for Mehmet Somel

Mehmet Somel

Middle East Technical University
Verified email at metu.edu.tr
Cited by 6551

Million-year-old DNA sheds light on the genomic history of mammoths

…, E Sağlıcan, FR Fidan, I Barnes, S Liu, M Somel… - Nature, 2021 - nature.com
Temporal genomic data hold great potential for studying evolutionary processes such as
speciation. However, sampling across speciation events would, in many cases, require …

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA

…, N Vinckenbosch, YU Liang, X Yi, M He, M Somel… - Nature, 2014 - nature.com
As modern humans migrated out of Africa, they encountered many new environmental
conditions, including greater temperature extremes, different pathogens and higher altitudes. …

[HTML][HTML] A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

…, K Hammerschmidt, SM Hölter, T Blass, M Somel… - Cell, 2009 - cell.com
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have
been positively selected during human evolution due to effects on aspects of speech and …

[PDF][PDF] The demographic development of the first farmers in Anatolia

…, YS Erdal, YG Çakan, I Togan, M Somel… - Current Biology, 2016 - cell.com
The archaeological documentation of the development of sedentary farming societies in
Anatolia is not yet mirrored by a genetic understanding of the human populations involved, in …

Human brain evolution: transcripts, metabolites and their regulators

M Somel, X Liu, P Khaitovich - Nature Reviews Neuroscience, 2013 - nature.com
What evolutionary events led to the emergence of human cognition? Although the genetic
differences separating modern humans from both non-human primates (for example, …

[HTML][HTML] Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears

…, K Harris, Z Xiong, L Zhou, TS Korneliussen, M Somel… - Cell, 2014 - cell.com
Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic
physiological changes in response to Arctic climates and a hyperlipid diet of primarily marine …

MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain

M Somel, S Guo, N Fu, Z Yan, HY Hu, Y Xu… - Genome …, 2010 - genome.cshlp.org
Changes in gene expression levels determine differentiation of tissues involved in development
and are associated with functional decline in aging. Although development is tightly …

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques

X Liu, M Somel, L Tang, Z Yan, X Jiang, S Guo… - Genome …, 2012 - genome.cshlp.org
Over the course of ontogenesis, the human brain and human cognitive abilities develop in
parallel, resulting in a phenotype strikingly distinct from that of other primates. Here, we used …

[PDF][PDF] Variable kinship patterns in Neolithic Anatolia revealed by ancient genomes

…, CJ Knüsel, A Götherström, F Özer, M Somel - Current Biology, 2021 - cell.com
The social organization of the first fully sedentary societies that emerged during the Neolithic
period in Southwest Asia remains enigmatic, 1 mainly because material culture studies …

Transcriptional neoteny in the human brain

M Somel, H Franz, Z Yan, A Lorenc… - Proceedings of the …, 2009 - National Acad Sciences
In development, timing is of the utmost importance, and the timing of developmental processes
often changes as organisms evolve. In human evolution, developmental retardation, or …