To the Editor: CRISPR-Cas systems have been developed as an efficient gene editing
technology in cells and model organisms. Here we use a CRISPR-Cas system to induce genomic …

Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their
bystander mutations and off-target editing effects raise safety concerns. Through structure-…

Conventional embryonic stem cell (ESC)–based gene targeting, zinc-finger nuclease (ZFN)
and transcription activator–like effector nuclease (TALEN) technologies are powerful …

Microglia are important immune cells in the central nervous system (CNS) that undergo
turnover throughout the lifespan. If microglial debris is not removed in a timely manner, …

Cytidine base editors are powerful genetic tools that catalyse cytidine to thymidine conversion
at specific genomic loci, and further improvement of the editing range and efficiency is …

Transcription activator-like effector nucleases (TALENs) are a powerful new approach for
targeted gene disruption in various animal models, but little is known about their activities in …

The CRISPR-Cas RNA-guided system has versatile uses in many organisms and allows
modification of multiple target sites simultaneously. Generating novel genetically modified …

Biomass resources originally produced by photosynthesis and their biodegradable derivatives
such as crop straw, vegetable waste, livestock and poultry manure, etc., can be used as …

In our previous studies, vitamin C (VC) exerts potent pharmacological activities against liver
injury (LI). Therefore, this report was designed to use network pharmacology-based strategy …

Developing effective and “green” approaches to handle aquatic pollution problems is currently
one of the most important research subjects of environmental remediation. In this paper, …