A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

The crystal structure of the diphtheria toxin dimer at 2.5 Å resolution reveals a Y-shaped
molecule of three domains. The catalytic domain, called fragment A, is of the α + β type. …

3D domain swapping is a mechanism for forming oligomeric proteins from their monomers. In
3D domain swapping, one domain of a monomeric protein is replaced by the same domain …

HFE is an MHC-related protein that is mutated in the iron-overload disease hereditary
hemochromatosis. HFE binds to transferrin receptor (TfR) and reduces its affinity for iron-loaded …

The aldo–keto reductases metabolize a wide range of substrates and are potential drug
targets. This protein superfamily includes aldose reductases, aldehyde reductases, …

HFE is related to major histocompatibility complex (MHC) class I proteins and is mutated in
the iron-overload disease hereditary haemochromatosis. HFE binds to the transferrin …

Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells
and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and …

The transferrin receptor (TfR) interacts with two proteins important for iron metabolism,
transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis. A second receptor …

Publisher Summary This chapter examines one type of interchain, noncovalent protein-protein
bond: 3D domain swapping. To date, 3D domain swapping has been definitively …

Protein aggregation is a feature of both normal cellular assemblies and pathological protein
depositions. Although the limited order of aggregates has often impeded their structural …