The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic 1 , 2 , 3 , 4 , 5 . Studies of sensory …

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …

Current therapies for common types of cancer such as renal cell cancer are often ineffective
and unspecific, and novel pharmacological targets and approaches are in high demand. …

Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1
channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell …

Background and Purpose The mechanosensitive Piezo1 channel has important roles in
vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology of …

Piezo1 is a mechanosensitive cation channel with widespread physiological importance;
however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve …

The concentration of free cytosolic Ca 2+ and the voltage across the plasma membrane are
major determinants of cell function. Ca 2+ -permeable non-selective cationic channels are …

Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable,
non‐selective cation channels in numerous cell types from several species. Options for …

Piezo1 forms a mechanically activated calcium-permeable nonselective cation channel that
is functionally important in many cell types. Structural data exist for C-terminal regions, but …

Background and Purpose The TRPC5 proteins assemble to create calcium‐permeable, non‐selective,
cationic channels. We sought novel modulators of these channels through …