[HTML][HTML] Albumin-induced podocyte injury and protection are associated with regulation of COX-2
S Agrawal, AJ Guess, MA Chanley, WE Smoyer - Kidney international, 2014 - Elsevier
Albuminuria is both a hallmark and a risk factor for progressive glomerular disease, and results
in increased exposure of podocytes to serum albumin with its associated factors. Here in …
in increased exposure of podocytes to serum albumin with its associated factors. Here in …
[HTML][HTML] Predicting and defining steroid resistance in pediatric nephrotic syndrome using plasma proteomics
…, DW Wilkey, AE Gaweda, ME Brier, MA Chanley… - Kidney international …, 2020 - Elsevier
Introduction Nephrotic syndrome (NS) is a characterized by massive proteinuria, edema,
hypoalbuminemia, and dyslipidemia. Glucocorticoids (GCs), the primary therapy for >60 years, …
hypoalbuminemia, and dyslipidemia. Glucocorticoids (GCs), the primary therapy for >60 years, …
Disease severity correlates with thrombotic capacity in experimental nephrotic syndrome
…, AP Waller, R Sharma, MA Chanley… - Journal of the …, 2015 - journals.lww.com
Thrombotic disease, a major life–threatening complication of nephrotic syndrome, has been
associated with proteinuria and hypoalbuminemia severity. However, it is not fully …
associated with proteinuria and hypoalbuminemia severity. However, it is not fully …
[HTML][HTML] Whole transcriptome analysis of renal intercalated cells predicts lipopolysaccharide mediated inhibition of retinoid X receptor alpha function
…, J Fitch, J Ketz, P White, A Wetzel, MA Chanley… - Scientific Reports, 2019 - nature.com
The renal collecting duct consists of intercalated cells (ICs) and principal cells (PCs). We have
previously demonstrated that collecting ducts have a role in the innate immune defense of …
previously demonstrated that collecting ducts have a role in the innate immune defense of …
Nephrotic syndrome‐associated hypercoagulopathy is alleviated by both pioglitazone and glucocorticoid which target two different nuclear receptors
…, KJ Wolfgang, J Kino, MA Chanley… - Physiological …, 2020 - Wiley Online Library
Background Thrombosis is a potentially life‐threatening nephrotic syndrome (NS) complication.
We have previously demonstrated that hypercoagulopathy is proportional to NS severity …
We have previously demonstrated that hypercoagulopathy is proportional to NS severity …
Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome
X Nie, MA Chanley, R Pengal… - American Journal …, 2018 - journals.physiology.org
The p38 MAPK pathway plays a crucial role in various glomerulopathies, with activation
being associated with disease and inhibition being associated with disease amelioration. We …
being associated with disease and inhibition being associated with disease amelioration. We …
Publisher Correction: Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha …
…, J Fitch, J Ketz, P White, A Wetzel, MA Chanley… - Scientific …, 2020 - ncbi.nlm.nih.gov
Furthermore, the p-Adjusted value for Prkar1b was missing from Table 2. The original Article
also contained a truncated Figure 5. There was an additional typographical error in the link …
also contained a truncated Figure 5. There was an additional typographical error in the link …
Nephrotic Syndrome-Associated Hypercoagulopathy is Alleviated by Nuclear Receptor Agonist Therapy with both Pioglitazone and Glucocorticoids
…, S Agrawal, KJ Wolfgang, J Kino, MA Chanley… - bioRxiv, 2020 - biorxiv.org
Background Thrombosis is a potentially life-threatening nephrotic syndrome (NS) complication.
We have previously demonstrated that hypercoagulopathy is proportional to NS severity …
We have previously demonstrated that hypercoagulopathy is proportional to NS severity …
[HTML][HTML] Thrombin Generation Is Directly Correlated To Proteinuria Severity In An Experimental Model Of Nephrotic Syndrome
AP Waller, WE Smoyer, MA Chanley, MT Nieman… - Blood, 2013 - Elsevier
Introduction Thromboembolism is a common complication of nephrotic syndrome (NS). The
massive urinary protein loss (proteinuria) of NS results in an acquired, complex …
massive urinary protein loss (proteinuria) of NS results in an acquired, complex …
Cell-specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct
…, DS Hains, J Ketz, M Chanley… - American Journal …, 2018 - journals.physiology.org
The urinary tract is usually culture negative despite its close proximity to microbial flora. The
precise mechanism by which the kidneys and urinary tract defends against infection is not …
precise mechanism by which the kidneys and urinary tract defends against infection is not …