User profiles for Melinda Bence

Melinda Bence

Institute of Genetics, Biological Research Centre, ELKH
Verified email at brc.hu
Cited by 726

Variants in CPA1 are strongly associated with early onset chronic pancreatitis

…, JM Chen, GR Chandak, A Masamune, M Bence… - Nature …, 2013 - nature.com
Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1,
encoding carboxypeptidase A1, in subjects with nonalcoholic chronic pancreatitis (cases) and …

[HTML][HTML] Oxytocin Receptor Gene Polymorphisms Are Associated with Human Directed Social Behavior in Dogs (Canis familiaris)

A Kis, M Bence, G Lakatos, E Pergel, B Turcsán… - PloS one, 2014 - journals.plos.org
The oxytocin system has a crucial role in human sociality; several results prove that
polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. …

Combining the auxin‐inducible degradation system with CRISPR/Cas9‐based genome editing for the conditional depletion of endogenous Drosophila melanogaster …

M Bence, F Jankovics, T Lukácsovich… - The FEBS …, 2017 - Wiley Online Library
Inducible protein degradation techniques have considerable advantages over classical
genetic approaches, which generate loss‐of‐function phenotypes at the gene or mRNA level. …

Drosophila small ovary gene is required for transposon silencing and heterochromatin organization, and ensures germline stem cell maintenance and differentiation

F Jankovics, M Bence, R Sinka, A Faragó… - …, 2018 - journals.biologists.com
Self-renewal and differentiation of stem cells is one of the fundamental biological phenomena
relying on proper chromatin organization. In our study, we describe a novel chromatin …

[HTML][HTML] Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2

R Szmola, M Bence, A Carpentieri, A Szabó… - Journal of biological …, 2011 - ASBMB
Human digestive carboxypeptidases CPA1, CPA2, and CPB1 are secreted by the pancreas
as inactive proenzymes containing a 94–96-amino acid-long propeptide. Activation of …

[HTML][HTML] Complex formation of human proelastases with procarboxypeptidases A1 and A2

A Szabó, C Pilsak, M Bence, H Witt… - Journal of Biological …, 2016 - ASBMB
The pancreas secretes digestive proenzymes typically in their monomeric form. A notable
exception is the ternary complex formed by proproteinase E, chymotrypsinogen C, and …

Lessons from the canine Oxtr gene: populations, variants and functional aspects

M Bence, P Marx, E Szantai, E Kubinyi… - Genes, Brain and …, 2017 - Wiley Online Library
Oxytocin receptor ( OXTR ) acts as a key behavioral modulator of the central nervous system,
affecting social behavior, stress, affiliation and cognitive functions. Variants of the Oxtr gene …

[HTML][HTML] Oxytocin and opioid receptor gene polymorphisms associated with greeting behavior in dogs

E Kubinyi, M Bence, D Koller, M Wan, E Pergel… - Frontiers in …, 2017 - frontiersin.org
Meeting humans is an everyday experience for most companion dogs, and their behavior in
these situations and its genetic background is of major interest. Previous research in our …

Direct interaction of Su(var)2‐10 via the SIM‐binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster

M Bence, F Jankovics, I Kristó, Á Gyetvai… - The FEBS …, 2024 - Wiley Online Library
Nuclear Piwi/Piwi‐interacting RNA complexes mediate co‐transcriptional silencing of
transposable elements by inducing local heterochromatin formation. In Drosophila, sumoylation …

Asparagine‐linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity

M Bence, M Sahin‐Tóth - The FEBS journal, 2011 - Wiley Online Library
Human chymotrypsin C (CTRC) plays a protective role in the pancreas by mitigating premature
trypsinogen activation through degradation. Mutations that abolish activity or secretion of …