Estimating age based on neuroimaging‐derived data has become a popular approach to
developing markers for brain integrity and health. While a variety of machine‐learning …

The concept of brain maintenance refers to the preservation of brain integrity in older age,
while cognitive reserve refers to the capacity to maintain cognition in the presence of …

Brain age is becoming a widely applied imaging-based biomarker of neural aging and potential
proxy for brain integrity and health. We estimated multimodal and modality-specific brain …

Pregnancy involves maternal brain adaptations, but little is known about how parity influences
women's brain aging trajectories later in life. In this study, we replicated previous findings …

Study Objectives To examine the association between sleep duration trajectories over 28
years and measures of cognition, gray matter volume, and white matter microstructure. We …

Background Trajectories of depressive symptoms over the lifespan vary between people, but
it is unclear whether these differences exhibit distinct characteristics in brain structure and …

Introduction: This study aimed to evaluate whether engagement in leisure activities is linked
to measures of brain structure, functional connectivity, and cognition in early old age. …

Importance Prior neuroimaging studies have found that late-life participation in cognitive (eg,
reading) and social (eg, visiting friends and family) leisure activities are associated with …

We characterize the associations of total cerebral small vessel disease (SVD) burden with
brain structure, trajectories of vascular risk factors, and cognitive functions in mid-to-late life. …

Background Automated tools for characterising dementia risk have the potential to aid in the
diagnosis, prognosis, and treatment of Alzheimer’s disease (AD). Here, we examined a …