The Carnivora are one of only four orders of terrestrial mammals living in Madagascar today.
All four (carnivorans, primates, rodents and lipotyphlan insectivores) are placental …

The aberrant activation of tyrosine kinases represents an important oncogenic mechanism,
and yet the majority of such events remain undiscovered. Here we describe a bead-based …

Diagnostic advancements for prostate cancer have so greatly increased early detections
that hope abounds for improved patient outcomes. However, histopathology, which guides …

10.7554/eLife.10565.001 Transposons are mobile genetic elements that are found in nearly
all organisms, including humans. Mobilization of DNA transposons by transposase enzymes …

There is growing evidence supporting an inherited basis for susceptibility to acute lymphoblastic
leukemia (ALL) in children. In particular, we and others reported recurrent germline …

Background/objectives While outcomes for pediatric T‐cell acute lymphoblastic leukemia (T‐ALL)
are favorable, there are few widely accepted prognostic factors, limiting the ability to …

The role of Hedgehog signaling in normal and malignant T-cell development is controversial.
Recently, Hedgehog pathway mutations have been described in T-ALL, but whether …

This phylogenetic study focuses on a subset of the species in Elymus—specifically, the endemic
Asian tetraploids presumed to combine the St genome from Pseudoroegneria with the Y …

The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called
mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully …

Pairings of a CS and unconditioned stimulus/stimuli (UCS) stimulus can result in approach
to either the CS (sign tracking) or the UCS (goal tracking). Increasing the spatial or temporal …