Metabolic imaging of the relative amounts of reduced NADH and FAD and the microenvironment
of these metabolic electron carriers can be used to noninvasively monitor changes in …

Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

Multiphoton fluorescence lifetime imaging microscopy (FLIM) is a noninvasive, cellular
resolution, 3-D functional imaging technique. We investigate the potential for in vivo precancer …

The unique metabolic demands of cancer cells underscore potentially fruitful opportunities
for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer …

Abnormal cellular metabolism is a hallmark of cancer, yet there is an absence of quantitative
methods to dynamically image this powerful cellular function. Optical metabolic imaging (…

There is a need for technologies to predict the efficacy of cancer treatment in individual patients.
Here, we show that optical metabolic imaging of organoids derived from primary tumors …

This study characterizes the morphologic features and the endogenous fluorescence in the
stratified squamous epithelia of the 7,12-dimethylbenz(a)anthracene-treated hamster cheek …

Numerous protocols have been described for producing neural retina from human pluripotent
stem cells (hPSCs), many of which are based on the culture of 3D organoids. Although …

The move from reading to writing the human genome offers new opportunities to improve
human health. The United States National Institutes of Health (NIH) Somatic Cell Genome …

A new microparticle-based delivery system was synthesized from reactive oxygen species (ROS)-responsive
poly(propylene sulfide) (PPS) and tested for “on demand” antioxidant …